Selective Thrombosis of Tumor Blood Vessels in Mammary Adenocarcinoma Implants in Rats
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چکیده
منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Selective targeted delivery of TNF to tumor blood vessels
We sought to enhance the selective toxicity of tumor necrosis factor (TNF ) to permit its systemic use in cancer therapy. Because ligand-targeted therapeutics have proven successful in improving the selective toxicity of drugs, we prepared a fusion protein (L19mTNF ) composed of mouse TNF and a high-affinity antibody fragment (L19 scFv) to the extradomain B (ED-B) domain of fibronectin, a marke...
متن کاملSelective targeted delivery of TNF to tumor blood vessels
We sought to enhance the selective toxicity of tumor necrosis factor (TNF ) to permit its systemic use in cancer therapy. Because ligand-targeted therapeutics have proven successful in improving the selective toxicity of drugs, we prepared a fusion protein (L19mTNF ) composed of mouse TNF and a high-affinity antibody fragment (L19 scFv) to the extradomain B (ED-B) domain of fibronectin, a marke...
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15 صفحه اولSelective targeted delivery of TNFα to tumor blood vessels . Short title: Delivery of TNFα to tumor vessels. Scientific Section Heading: Hemostasis, Thrombosis & Vascular Biology
We sought to enhance the selective toxicity of tumor necrosis factor alpha (TNFα) in order to permit its systemic use in cancer therapy. Since ligand-targeted therapeutics has proven successful in improving the selective toxicity of drugs, we prepared a fusion protein (L19mTNFα) composed of mouse TNFα and a high affinity antibody fragment (L19 scFv) to the ED-B domain of fibronectin, a marker o...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2001
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)61690-2